Evaluation of the relationship between insulin resistance and different phenotypes of polycystic ovary syndrome

Aims: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women. Hyperinsulinemia and insulin resistance (IR) are the most important metabolic abnormalities that affect these patients. This study aimed to investigate variables related IR patients with different PCOS phenotypes.
 Methods: retrospective included 389 women diagnosed Bezmialem Hospital between november 2020 september 2022. Information about was collected through their electronic records. based on Rotterdam criteria, four phenotypes of A (oligoovulation+ hyperandrogenism+PCO), B (oligoovulation+hyperandrogenism), C (hyperandrogenism +PCO), D (oligoovulation+absent PCO) were considered for PCOS. The homeostatic model assessment ınsulin (HOMA-IR) used evaluate IR. Mann-Whitney U test performed difference groups.
 Results: highest value HOMA-IR phenotype group, lowest group. However, groups not significant (p=0.221). Estradiol free T4 significantly higher group (p≤0.001). Thyroid-stimulating hormone (TSH), prolactin, anti-mullerian (AMH), fasting insulin, total testosterone, red blood cell distribution width (RDW) Total cholesterol, high density lipoprotein (HDL), leukocyte, basophil, monocyte Also, MPV values (p≤0.001).
 Conclusion: results showed than other phenotypes.